Chromatographic Resolution of Racemic Compounds Containing Phosphorus or Sulfur Atom as Chiral Center

Review High-performance liquid chromatographic enantioseparation of drugs containing multiple chiral centers on chiral stationary phases

In recent years there has been considerable interest in the synthesis and separation of enantiomers of organic compounds especially because of their importance in the biochemistry and pharmaceutical industry. High-performance liquid Chromatography is a very useful method for the direct separation of enantiomers. However, about 30−40 years ago, commercially available chiral stationary phases wer...

Extractive Resolution of Racemic Mandelic Acid through a Bulk Liquid Membrane Containing Binary Chiral Carrier

Um método empregando “bulk liquid membrane” (BLM) e o complexo ácido di(2-etilhexil) fosfórico (D2EHPA) e ácido O,O’-dibenzoil-(2R, 3R)-tartárico (L-(-)-DBTA) foi desenvolvido para a separação por extração do ácido mandélico racêmico (rac MA). Os efeitos de tempo de resolução, concentração de D2EHPA na fase orgânica, concentração de rac MA na fase doadora, velocidade de agitação e temperatura s...

Some nitrogen and sulfur containing compounds as chemotherapeutic agents.

Sulfur-containing compounds from Clinacanthus siamensis.

Two new sulfur-containing compounds, trans-3-methylsulfonyl-2-propenol (1) and trans-3-methylsulfinyl-2-propenol (2) were isolated together with trans-3-methylthioacrylamide (3), entadamide A (4) and entadamide C (5) from the leaves of Clinacanthus siamensis. The structures were established on the basis of the spectroscopic data. The compounds were tested for antimalarial and antimycobacterial ...

Gas chromatographic determination of phosphorus-containing pesticide metabolites via benzylation.

Monoand di-protic alkyl and aryl phosphates, phosphonates, and thio analogues were determined in spiked samples of bacterial growth medium and human urine using a new procedure wlth a detection llmit of less than 2 pmol each. The acids were fully protonated by passing the aqueous samples through BioRad AG 50W-X8 (H') resin and dried thoroughly before refluxing with 3-benzyl-1-p-tolyltriazene in...